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Discusses the substantial variation in mortality rates and patterns by geographic region in the United States, with specific regions showing elevated mortality for causes such as cardiovascular disease, violence, and respiratory conditions.

Dwyer-Lindgren L, Bertozzi-Villa A, Stubbs RW et al. US county-level trends in mortality rates for major causes of death, 1980–2014. JAMA 2016;316: 2385-2401.