About diet



Suggests that consuming a Western diet can have a negative impact on gut permeability and blood-brain barrier integrity, affecting neurocognitive function.

Noble EE, Hsu TM, Kanoski SE. Gut to brain dysbiosis: mechanisms linking Western diet consumption, the microbiome, and cognitive impairment. Frontiers in Behavioral Neuroscience 2017;11: 9.


Reports on a pilot study exploring dietary manipulation as a means of affecting the composition and function of the gut microbiota.

Norin E, Engstrand L, Hellstrom P et al. FIBFLO—a study design for comparing the effects of diets on the microbiome and its metabolism: ß-glucan or not? Microbial Ecology in Health and Disease 2017;28(Suppl 1): Article 1281946.




Describes research pointing to a potential link between artificial sweeteners and health problems such as metabolic syndrome and obesity. Complementary research suggests that the sweeteners have a negative effect on friendly gut bacteria.

Fowler SPG, Williams K, Hazuda HP. Diet soda intake is associated with long-term increases in waist circumference in a biethnic cohort of older adults: the San Antonio Longitudinal Study of Aging. Journal of the American Geriatrics Society 2015;63(4): 708-715.

Suez J, Korem T, Zeevi D, et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature 2014;514: 181-186.

See also, “Study suggests diet soda may lead to belly fat. Critics aren’t so sure.” Forbes, Mar. 17, 2015.


Introduces a special issue of the journal Gastroenterology focusing on food, the immune system, and the gastrointestinal tract. Topics include food allergies, celiac disease, non-celiac wheat sensitivity, carbohydrate intolerance in relation to irritable bowel syndrome, cancer, obesity and brain-gut interactions.

Gastroenterology 2015;148(6): 1083-1260.
See also,Gastroenterology special issue confirms: you are what you eat,” EurekAlert!, Apr. 27, 2015.


Suggests that the increasing interest in using diet to manage irritable bowel syndrome (IBS) requires greater understanding of the mechanisms underlying dietary intervention.

Gibson PR, Varney J, Malakar S et al. Food components and irritable bowel syndrome. Gastroenterology 2015;148(6): 1158-1174.e4.


Discusses the use of diets that restrict deleterious components but supplement beneficial nutrients to modify the intestinal microbiome of patients with inflammatory bowel diseases (IBDs).

Lee D, Albenberg L, Compher C et al. Diet in the pathogenesis and treatment of inflammatory bowel diseases. Gastroenterology 2015;148(6): 1087-1106.


Reports on a two-week experiment suggesting that modern low-fiber, high-sugar Western diets are bad for us and have an impact on gut health.

O’Keefe SJD, Li JV, Lahti L et al. Fat, fiber and cancer risk in African Americans and rural Africans. Nature Communication 2015;6: 6342.

See also, “Diet swap experiment reveals junk food’s harm to gut,” BBC News, Apr. 28, 2015.


Discusses short- and long-term effects of nutrients in shaping the composition of the gut microbiota, and suggests that Western diets may be responsible for promoting inflammation.

Tilg H, Moschen AR. Food, immunity, and the microbiome. Gastroenterology 2015;148(6): 1107-1119.